Controlled clinical studies assessing a product’s ability to reduce the appearance of skin redness and irritation following induced skin challenge conditions.
What you can expect from Anti Inflammation Product Trials
Study design is tailored depending on the type of anti-inflammatory product being evaluated. All testing is conducted on cosmetic, toiletry, or personal care products only, and is not intended to assess medicinal or therapeutic claims.
These studies typically focus on the visible appearance of skin redness and irritation, assessing changes before and after product application under controlled conditions.
Study Design Overview
Anti-inflammatory clinical trials generally involve a controlled skin challenge model to induce temporary, standardised skin redness for assessment purposes.
Commonly, this may involve the use of sodium lauryl sulfate (SLS) or controlled UV exposure, calibrated to a defined Minimal Erythema Dose (MED), typically up to approximately 4× MED depending on protocol requirements and ethical approval.
Following induction, both treated and untreated control sites are monitored over time to observe the natural resolution of visible redness and irritation, with and without product application.
Assessment Methods
Throughout the study, skin sites are evaluated using a combination of:
- Clinical visual grading of redness and irritation
- Standardised photography for comparative assessment
- Trained assessor scoring at defined time points
- Optional instrumental measurement of skin colour changes (where applicable)
This allows for both objective and qualitative evaluation of skin response over the study period.
Endpoints and Evaluation
The primary endpoint of these studies is the rate and degree of visible recovery in skin appearance, comparing treated versus untreated sites.
Observations continue until the induced redness has resolved to baseline or near-baseline appearance.
Claims Substantiated
Data from anti-inflammatory testing can support cosmetic claims such as:
- Reduces the appearance of skin redness
- Helps soothe and calm the skin
- Supports skin recovery after irritation
- Improves overall skin comfort and appearance