Clinical Trials For Nail Products

Tewameter (TEWL) Assessments:

• 15 subjects – Product versus no treatment with assessments at t=0h, t=1hr, t=8hrs. This assessment is normally used for emollients – a moisturizer that acts as film over the skin to improve skin barrier functionality between the skin and the exterior environment. We measure the Trans-Epidermal Water Loss – the amount of water lost across the epidermis – which makes it possible to measure the invisible, yet steady evaporation of water through the epidermis.
• Active Phase: The ‘open cylinder’ method consists of two moisture sensors coupled with temperature sensors inside a cylindrical probe that is placed on the skin. It is in this probe that the temperature and the moisture content of the rising water vapor are measured and the TEWL rate is calculated as grams per square meter per hour (g/m2h). Should the barrier function of the skin be impaired in any way, this leads to a dramatic rise in the TEWL value. Study design is similar to humectant products.